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60. McLaughlin K, Coren G, Masters J, Brown R. Binding activities of cis-platin-damage-recognition proteins in human tumor cell lines. Int J Cancer 1993; 53: 662-6.

61. Brown R, Hirst GL, Gallagher WM, McIlwrath AJ, Margison GP, Zee AG, Anthoney DA. HMLN1 expression and cellular responses of ovarian tumor cells to treatment with cytotoxic anticancer agents. Oncogene 1997, 15(1): 45-52.

62. Lanzi C, Perego P, Supino R, Romanelli S, Pensa T, Carenini N, Viano I, Colangelo D, Leone R, Apostoli P, Cassinelli G, Gambetta RA, Zunino F. Decreased drug accumulation and increased tolerance to DNA damage in tumor cells with a low level of cisplatin resistance. Biochem Pharmacol 1998, 55(8): 1247-54.

63. Fishel R, Ewel A, Lescoe MC. Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res 1994; 54: 5539-42.

64. Loeb LA. Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res 1994; 54: 5059-63.

65. Chu G. Cellular responces to Cisplatin. J Biol Chem 1994; 269: 787-90.

66. Sorenson CM, Eastman A. Influence of cis-Diamminedichloroplatinum (II) on DNA synthesis and cell cycle progression in excision repair proficient and deficient hamster ovary cells. Cancer Res 1988; 48: 6703-7.

67. Li Q, Gardner K, Zhang L, Tsang B, Bostick-Bruton F, Reed E. Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells. J Biol Chem 1998, 273 (36): 23419-25.

68. Husain A, He G, Venkatraman ES, Spriggs DR. BRCA1 up-regulation is associated with repair-mediated resistance to cis-diamminedichloroplatinum (II). Cancer Res 1998, 58 (6): 1120-3.

69. Mestdach N, Pommery N, Saucier JM, Hecquet B, Founier C, Slomianny C, Teissier E, Henichart JP. Chemoresistance to doxorubicin and cisplatin in a murine cell line. Analysis of P-Glycoprotein, topoisomerase II activity, glutathione and related enzymes. Anticancer Res 1994; 14: 869-74.

70. Kondo H, Kanzawa F, Nishio K, Saito S, Saijo N. In vitro and in vivo effects of cisplatin and etoposide in combination on small cell lung cancer cell lines. Jpn J Cancer Res 1994; 85: 1050-6.

71. Jong S, Timmer-Bosscha H, Vries EGE, Mulder NH. Effect of novobiocin on cisplatin cytotoxicity and DNA interstrand cross-link formation in a cisplatin-resistant, small-cell lung carcinoma cell line. Int J Cancer 1993; 53: 110-7.

72. Guchelaar H-J, Timmer-Bosscha H, Dam-Meiring A, Uges DRA, Oosterhuis JW, Vries EGE Mulder NH. Enhancement of cisplatin and etoposide cytotoxicity after all-trans retinoic-acid-induced cellular differentiation of a murine embryonal carcinoma cell line. Int J Cancer 1993; 55: 442-7.

73. Seki S, Hongo A, Zhang B, Akiyama K, Sarker AH, Kudo T. Inhibition of cisplatin-mediated DNA damage in vitro by ribonucleotides. Jpn J Cancer Res 1993; 84: 462-7.

74. Parekh HK, Simpkins H. The differential expression of citokeratin 18 in cisplatin-sensitive and -resistant human ovarian adenocarcinoma cells and its association with drug sensitivity. Cancer Res 1995; 55: 5203-6.

75. Mirakhur B, Parekh HK, Simpkins H. Expression of the cisplatin resistance phenotype in a human ovarian carcinoma cell line segregates with chromosomes 11 and 16. Cancer Res 1996; 56: 2256-62.

76. Mueller H, Eppeberger U. The dual role of mutant p 53 protein in chemosensitivity of human cancers. Anticancer Res 1996, 16 (6B): 3845-8.

77. Kawasaki t, Tomita Y, Bilim V, Takeda M, Takahashi K, Kumanishi T. Abrogation of apoptosis induced by DNA-damaging agents in human bladder-cancer cell lines with p 21/WAF1/CIP1 and/or p 53 gene alterations. Int J Cancer 1996, 68 (4): 501-5.

78. Kondo S, Barna BP, Kondo Y, Tanaka Y, Casey G, Liu J, Morimura T, Kaakaji R, Peterson JW, Werbel B, Barnett GH. WAF1/CIP1 increases the susceptibility of p 53 non-functional malignant glioma cells to cisplatin-induced apoptosis. Oncogene 1996, 13 (6): 1279-85.

79. Li G, Tang L, Zhou X, Tron V, Ho V. Chemotherapy-induced apoptosis in melanoma cells is p 53 dependent. Melanoma Res 1998, 8 (1): 17-23.

80. Biagosklonny MV, El-Deiry WS. Acute overexpression of wt p 53 facilitates anticancer drug-induced death of cancer and normal cells. Int J Cancer 1998, 75 (6): 933-940.

81. Li R, Sutphin PD, Schwartz D, Matas D, Almog N, Wolkowicz R, Goldginger N, Pei H, Prokocimer M, Rotter V. Mutant p 53 protein interferes with p 53-independent apoptotic pathways. Oncogene 1998, 16 (25): 3269-77.

82. Vasey PA, Jones NA, Jenkins S, Dive C, Broun R. Cisplatin, camptothecin, and taxol sensitivities of cells with p 53-associated multidrug resistance. Mol Pharmacol 1996, 50 (6): 1536-40.

83. Vikhanskaya F, Clerico L, Valenti M, Stazione NS, Broggini M, Parodi S, Russo P. Mechanism of resistance to cisplatin in a human ovarian-carcinoma cell line selected for resistance to doxorubicin: possible role of p 53. Int J Cancer 1997, 72 (1): 155-9.

84. Vaisman A, Varchenko M, Said I, Chaney SG. Cell cycle changes associated with formation of Pt-DNA adducts in human ovarian carcinoma cells with different cisplatin sensitivity. Cytometry 1997, 27 (1): 54-64.

85. Siddik ZH, Mims B, Lozano G, Thai G. Independent pathways of p 53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. Cancer Res 1998, 58 (4): 698-703.

86. Ju JF, Banerjee D, Lenz HJ, Danenberg KD, Schmittgen TC, Spreas CP, Schonthal AH, Manno DJ, Hochhauser D, Bertino JR, Danenberg PV. Restoration of wild-type p 53 activity in p 53-null HL-60 cells confers multidrug sensitivity. Clin Cancer Res 1998, 4 (5): 1315-22.

87. Fajac A, Da Silva J, Ahomadegbe JC, Rateau JG, Bernaudin JF, Riou G, Benard J. Cisplatin-induced apoptosis and p 53 gene status in a cisplatin-resistant human ovarian carcinoma cell line. Int J Cancer 1996, 86 (1): 67-74.

88. Kondo S, Barna BP, Morimura T, Takeuchi J, Yuan J, Akbasak A, Barnett GH. Interleukin-1-beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells. Cancer Res 1995, 55 (24): 6166-71.

89. De Feudis P, Debernardis D, Beccaglia P, Valenti M, Sire GE, Arzani D, Stanzione S, Parodi S, D`Incalci M, Russo P, Broggini M. DDP-induced cytotoxicity is not influenced by p 53 in nine human ovarian cancer cell lines with different p 53 status. Br J Cancer 1997, 76 (4): 474-9.

90. Burger H, Nooter K, Boersma AW, Kortland CJ, Stoter G. Expression of p 53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumor cell lines. Br J Cancer 1998, 77 (10): 1562-7.

91. Ikeguchi M, Tatebe S, Kaibara N, Ito H. Changes in levels of expression of p 53 and the product of the bcl-2 in lines of gastric cancer cells during cisplatin-induced apoptosis. Eur Surg Res 1997, 29 (5), 396-402.

92. Pestell KE, Medlow CJ, Titley JC, Kelland LR, Walton MI. Characterisation of the p 53 status, BCL-2 expression and radiation and platinum drug sensitivity of a panel of human ovarian cancer cell lines. Int J Cancer 1998, 77 (6): 913-8.

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